Synthroid® (levothyroxine sodium tablets, USP) Good

Please see Full Prescribing
Info & BOXED WARNING

IMPORTANT SAFETY INFORMATION AND USE

IMPORTANT SAFETY
INFORMATION

Thyroid hormones,
including SYNTHROID,
should not be used either
alone or in combination
with other drugs for the
treatment of obesity or
weight loss. In patients with
normal thyroid levels, doses
of SYNTHROID used daily
for hormone replacement
are not helpful for weight
loss. Larger doses may
result in serious or even
life-threatening events,
especially when used in
combination with certain
other drugs used to reduce
appetite.
Do not use SYNTHROID
if you have uncorrected
adrenal problems.
Use SYNTHROID only as
ordered by your doctor.
Taking too much or too
little SYNTHROID may
lead to negative effects on
growth and development,
heart function, bone health,
reproductive function,
mental health, digestive
function, and changes in
blood sugar and cholesterol
metabolism in adult or
pediatric patients.
Taking too much
levothyroxine may affect
your heart, especially if you
are elderly or have heart
disease. Tell your doctor
immediately if you have
any signs of increased
heart rate, chest pain, or an
irregular heartbeat.
Tell your doctor about any
other medical conditions
you may have, especially
heart disease, diabetes,
blood clotting problems,
and adrenal or pituitary
gland problems. The dose
of other drugs you may
be taking to control these
conditions may have to
be changed while you are
taking SYNTHROID. If you
have diabetes, check your
blood sugar levels and/or
the glucose in your urine, as
ordered by your doctor, and
immediately tell your doctor
if there are any changes.
If you are taking blood
thinners, your blood clotting
status should be checked
often.
Taking too much
levothyroxine has been
associated with increased
bone loss, especially in
women after menopause.
Tell your doctor if you are
pregnant or breastfeeding
or are thinking of becoming
pregnant while taking
SYNTHROID. Your dose of
SYNTHROID may need to
be increased during your
pregnancy.
Tell your doctor if you start
experiencing any of the
following symptoms: rapid
or abnormal heartbeat, chest
pain, difficulty catching
your breath, leg cramps,
headache, nervousness,
irritability, sleeplessness,
shaking, change in
appetite, weight gain or
loss, vomiting, diarrhea,
increased sweating,
difficulty tolerating heat,
fever, changes in menstrual
periods, swollen red bumps
on the skin (hives) or skin
rash, or any other unusual
medical event.
Partial hair loss may occur
during the first few months
you are taking SYNTHROID.
Tell your doctor if you are
taking any other drugs,
including prescription and
over-the-counter products.
Products such as iron
and calcium supplements
and antacids can lower
your body’s ability to
absorb levothyroxine, so
SYNTHROID should be
taken 4 hours before or after
taking these products.
Tell your doctor or dentist
that you are taking
SYNTHROID before any
surgery.
Use SYNTHROID only as
ordered by your doctor.
Take SYNTHROID as a single
dose, preferably on an
empty stomach, one-half to
one hour before breakfast.
Once your doctor has found
your specific SYNTHROID
dose, it is important to
have periodic lab tests and
clinical evaluations to assess
your treatment response.
Foods like soybean flour,
cottonseed meal, walnuts,
and dietary fiber may
cause your body to absorb
less SYNTHROID from
the gastrointestinal tract.
Grapefruit juice may cause
your body to absorb less
levothyroxine and may
reduce its effect. Let your
doctor know if you eat
these foods, as your dose of
SYNTHROID may need to be
adjusted.
It may take several weeks
before you notice an
improvement in your
symptoms.

This is the most important
safety information you
should know about
SYNTHROID. For more
information, talk with your
doctor.

USE

SYNTHROID® (levothyroxine
sodium) tablets, for oral
use is a prescription, man-
made thyroid hormone that
is used to treat a condition
called hypothyroidism in
adults and children, including
infants. It is meant to
replace a hormone that is
usually made by your thyroid
gland. Generally, thyroid
replacement treatment is to
be taken for life. SYNTHROID
should not be used to treat
noncancerous growths or
enlargement of the thyroid
in patients with normal
iodine levels, or in cases of
temporary hypothyroidism
caused by inflammation of the
thyroid gland (thyroiditis).

You are encouraged to report
negative side effects of
prescription drugs to the
FDA. Visit www.fda.gov/
medwatch or call 1-800-FDA-
1088.

If you are having difficulty
paying for your medicine,
AbbVie may be able to
help. Visit AbbVie.com/
PatientAccessSupport to learn
more.

Please see the full
Prescribing Information,
including BOXED WARNING,
or visit
https://www.rxabbvie.com/
pdf/synthroid.pdf.