Synthroid® (levothyroxine sodium tablets, USP) Good

Please see Full Prescribing Info & BOXED WARNING

IMPORTANT SAFETY INFORMATION AND USE

IMPORTANT SAFETY INFORMATION

Thyroid hormones, including SYNTHROID, should not
be used either alone or in combination with other drugs
for the treatment of obesity or weight loss. In patients
with normal thyroid levels, doses of SYNTHROID
used daily for hormone replacement are not helpful
for weight loss. Larger doses may result in serious or
even life-threatening events, especially when used in
combination with certain other drugs used to reduce
appetite.
Do not use SYNTHROID if you have uncorrected adrenal
problems.
Use SYNTHROID only as ordered by your doctor. Taking
too much or too little SYNTHROID may lead to negative
effects on growth and development, heart function, bone
health, reproductive function, mental health, digestive
function, and changes in blood sugar and cholesterol
metabolism in adult or pediatric patients.
Taking too much levothyroxine may affect your heart,
especially if you are elderly or have heart disease.
Tell your doctor immediately if you have any signs of
increased heart rate, chest pain, or an irregular heartbeat.
Tell your doctor about any other medical conditions
you may have, especially heart disease, diabetes,
blood clotting problems, and adrenal or pituitary gland
problems. The dose of other drugs you may be taking to
control these conditions may have to be changed while
you are taking SYNTHROID. If you have diabetes, check
your blood sugar levels and/or the glucose in your urine,
as ordered by your doctor, and immediately tell your
doctor if there are any changes. If you are taking blood
thinners, your blood clotting status should be checked
often.
Taking too much levothyroxine has been associated
with increased bone loss, especially in women after
menopause.
Tell your doctor if you are pregnant or breastfeeding
or are thinking of becoming pregnant while taking
SYNTHROID. Your dose of SYNTHROID may need to be
increased during your pregnancy.
Tell your doctor if you start experiencing any of the
following symptoms: rapid or abnormal heartbeat,
chest pain, difficulty catching your breath, leg cramps,
headache, nervousness, irritability, sleeplessness,
shaking, change in appetite, weight gain or loss, vomiting,
diarrhea, increased sweating, difficulty tolerating heat,
fever, changes in menstrual periods, swollen red bumps
on the skin (hives) or skin rash, or any other unusual
medical event.
Partial hair loss may occur during the first few months
you are taking SYNTHROID.
Tell your doctor if you are taking any other drugs,
including prescription and over-the-counter products.
Products such as iron and calcium supplements
and antacids can lower your body’s ability to absorb
levothyroxine, so SYNTHROID should be taken 4 hours
before or after taking these products.
Tell your doctor or dentist that you are taking
SYNTHROID before any surgery.
Use SYNTHROID only as ordered by your doctor. Take
SYNTHROID as a single dose, preferably on an empty
stomach, one-half to one hour before breakfast.
Once your doctor has found your specific SYNTHROID
dose, it is important to have periodic lab tests and clinical
evaluations to assess your treatment response.
Foods like soybean flour, cottonseed meal, walnuts,
and dietary fiber may cause your body to absorb less
SYNTHROID from the gastrointestinal tract. Grapefruit
juice may cause your body to absorb less levothyroxine
and may reduce its effect. Let your doctor know if you
eat these foods, as your dose of SYNTHROID may need
to be adjusted.
It may take several weeks before you notice an
improvement in your symptoms.

This is the most important safety information you should
know about SYNTHROID. For more information, talk with
your doctor.

USE

SYNTHROID® (levothyroxine sodium) tablets, for oral
use is a prescription, man-made thyroid hormone that
is used to treat a condition called hypothyroidism in
adults and children, including infants. It is meant to
replace a hormone that is usually made by your thyroid
gland. Generally, thyroid replacement treatment is to be
taken for life. SYNTHROID should not be used to treat
noncancerous growths or enlargement of the thyroid in
patients with normal iodine levels, or in cases of temporary
hypothyroidism caused by inflammation of the thyroid
gland (thyroiditis).

You are encouraged to report negative side effects
of prescription drugs to the FDA. Visit www.fda.gov/
medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine,
AbbVie may be able to help. Visit AbbVie.com/
PatientAccessSupport to learn more.

Please see the full Prescribing Information, including
BOXED WARNING, or visit
https://www.rxabbvie.com/pdf/synthroid.pdf.